In a world where supervillains are commonplace, two estranged childhood best friends Lydia (Melissa McCarthy) and Emily (Octavia Spencer) reunite after Emily devises a treatment that gives them the powers to protect their city.
While the pair have wildly different personalities — Lydia is a free spirit who
leaps without looking and Emily is a meticulous scientist—their lifelong bond of friendship sees them through their adventures.
With help from Emily’s daughter Tracy (Taylor Mosby), the two are ready to do
battle with the evil “Miscreants” including “The Crab” (Jason Bateman), “Laser” (Pom Klementieff), and their leader “The King” (Bobby Cannavale). Newly super, almost heroes.